Protection from Glutamate-Induced Excitotoxicity by Memantine
نویسندگان
چکیده
منابع مشابه
Effect of Memantine and Hespiridine on Monosodium Glutamate Induced Excitotoxicity in Rats
Background: Glutamate mediated excitotoxicity is proved to be involved in neurodegenerative diseases like ischemia, trauma, diabetic retinopathy, glaucoma, seizures. Development of specific glutamate antagonists favors a better treatment opportunity of these neurodegenerative diseases. Hesperidin, a proven antioxidant and memantine a known NMDA antagonist were selected and evaluated for their n...
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PURPOSE To determine which glutamate receptor (GluR) subtypes are responsible for glutamate-induced excitotoxicity in cultured adult pig retinal ganglion cells (RGCs) and to characterize the neuroprotective effect of acetylcholine (ACh) on pig RGCs. METHODS Adult pig RGCs were isolated from other retinal tissue by a modified panning technique using Thy 1.1 antibody. Isolated RGCs were culture...
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In cultured rat cerebellar granule cells, glutamate or N-methyl-d-aspartate (NMDA) activation of the NMDA receptor caused a sustained increase in cytosolic Ca(2+) levels ([Ca(2+)](i)), reactive oxygen species (ROS) generation, and cell death (respective EC(50) values for glutamate were 12, 30, and 38 microM) but no increase in caspase-3 activity. Removal of extracellular Ca(2+) blocked all thre...
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The neuroprotective activity of pyruvate has been confirmed in previous in vivo and in vitro studies. Here, we report a novel mechanism that pyruvate prevents SH-SY5Y cells from glutamate excitotoxicity by regulating death-associated protein kinase 1 (DAPK1) protein complex. Our results showed pyruvate regulated DAPK1 protein complex to protect cells by two ways. First, pyruvate induced the dis...
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ژورنال
عنوان ژورنال: Annals of Biomedical Engineering
سال: 2011
ISSN: 0090-6964,1573-9686
DOI: 10.1007/s10439-011-0494-z